Single-shot ultrasound-modulated optical tomography with enhanced speckle contrast

Ultrasound-modulated optical tomography (UOT) images contrast deep inside biological tissue. Among existing approaches, camera-based parallel detection is beneficial in modulation depth but limited to the relatively slow framerate of cameras. This condition prevents such a scheme from achieving maturity image live animals with sub-millisecond speckle correlation time. In this work, we developed on-axis single-shot UOT by investigating statistics speckles, breaking restriction imposed camera framerate. As proof concept, experimentally imaged one-dimensional absorptive object buried moving scattering medium time down 0.48 ms. We envision that promising cope fast decorrelation.